GPC2-CAR T cells tuned for low antigen density mediate potent

Por um escritor misterioso

Last updated 13 março 2025

GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Antigen density quantification of cell-surface immunotherapy targets by flow cytometry: Multi-antigen assay of neuroblastoma bone marrow metastasis - ScienceDirect

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Strategies to enhance CAR-T persistence, Biomarker Research

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

D3-GPC2-PBD is potently cytotoxic to GPC2-expressing SCLCs (A)

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges - ScienceDirect

Present Status and Advances in Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

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