Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children, International Journal of Emergency Medicine

Cerebrospinal fluid (CSF) lactate is a potential biomarker for bacterial meningitis in children. To this end, we performed a single-center retrospective cohort study of children from Sao Paulo, Brazil, with CSF pleocytosis to evaluate the ability of CSF lactate to distinguish between children with bacterial and aseptic meningitis. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. We identified 451 children of whom 40 (9%) had bacterial meningitis. Children with bacterial meningitis had a higher median CSF lactate level [9.6 mmol/l, interquartile range (IQR) 3.2-38.5 mmol/l bacterial meningitis vs. 2.0 mmol/l, IQR 1.2-2.8 mmol/l aseptic meningitis]. A CSF lactate cutoff point of 3.0 mmol/l had a sensitivity of 95% [95% confidence interval (CI) 83-99%), specificity of 94% (95% CI 90-96%) and negative predictive value of 99.3% (95% CI 97.7-99.9%) for bacterial meningitis. In combination with a validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and aseptic meningitis in children with CSF pleocytosis.

Cells, Free Full-Text

The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis.

Diagnostics, Free Full-Text

Dilemmas in the diagnosis of acute community-acquired bacterial meningitis - The Lancet

PDF] USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS

Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis

Diagnostic value of lactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers in bacterial and viral meningitis: A cross-sectional study. - Abstract - Europe PMC

PDF) Elevated lactate levels in the cerebrospinal fluid associated with bacterial meningitis

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

Lactate Triggers Invasion of Meningitis-Causing Bacteria into Blood

Full article: Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine deaminase in the diagnosis and outcome of acute meningitis

African Journal of Microbiology Research - etiological and predictive factors of acute meningitis in mansoura fever hospital, egypt

S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version), Neurological Research and Practice