Retrospective evaluation of labetalol as antihypertensive agent in

Background To evaluate the effect on arterial blood pressure (ABP) of labetalol infusion as treatment for perioperative non nociceptive acute hypertension in dogs. The clinical records of dogs receiving intra or postoperative labetalol infusion were retrospectively reviewed. Invasive systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressure and heart rate (HR) before labetalol infusion (T0) and 15, 30, 45 and 60 min (T1, T2, T3 and T4 respectively) after infusion were retrieved. The dose rate of labetalol infusion and use of concurrently administered drugs that could have potentially affected ABP and/or HR were also recorded. ANOVA for repeated measures and Dunnett’s multiple comparison test were used to determine the effect of labetalol on ABP and HR. Differences were considered significant when p < 0.05. Results A total of 20 dogs met the inclusion criteria, and hypertension was documented after craniotomy (12/20), adrenalectomy (4/20) and other procedures (4/20). Five dogs received labetalol intraoperatively, 14 postoperatively, and 1 during the surgical procedure and recovery. Median infusion duration and rate were 463 (60-2120) minutes and 1.1 (0.2–3.4) mg/kg/h respectively. Median loading dose was 0.2 (0.2–0.4) mg/kg. Labetalol produced a significant decrease in SAP and DAP at all time points compared to T0 (p < 0.05), while the effect was not significant at T1 for MAP (p = 0.0519). Median maximum MAP decrease was 31 (20–90) mmHg. Heart rate did not increase significantly during treatment (p = 0.2454). Acepromazine given before or during labetalol treatment did not reduce significantly ABP (p = 0.735). Conclusions Labetalol produced a reliable and titratable decrease in ABP with non significant increase in HR.

Optimal blood pressure target to prevent severe hypertension in pregnancy: A systematic review and meta-analysis

Cureus, Blood Pressure Control and Prescription Pattern of Antihypertensive Drugs in Adherence to the 2020 International Society of Hypertension (ISH) Global Hypertension Practice Guidelines in Saudi Arabia: A Retrospective Study

Frontiers Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke

JCM, Free Full-Text

Healthcare, Free Full-Text

Dilevalol: An Overview of Its Clinical Pharmacology and Therapeutic Use in Hypertension - Lalonde - 1990 - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Wiley Online Library

Retrospective evaluation of labetalol as antihypertensive agent in dogs, BMC Veterinary Research

Severe Asymptomatic Hypertension: Evaluation and Treatment

A systematic review of nicardipine vs labetalol for the management of hypertensive crises - ScienceDirect

A systematic review of nicardipine vs labetalol for the management of hypertensive crises.

Healthcare, Free Full-Text

IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy–A randomized controlled trial - ScienceDirect

Oral nifedipine versus intravenous labetalol in hypertensive urgencies and emergencies of pregnancy: a randomized clinical trial - B Sathya Lakshmi, Papa Dasari, 2012

SBP changes over time in patients randomized to receive either

PDF) Antihypertensive drugs in pregnancy Jose Geraldo Lopes Ramos