Viruses, Free Full-Text
Por um escritor misterioso
Last updated 21 outubro 2024
Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and Tri2B), and extend towards small capsid proteins atop nearby major capsid proteins, forming a net-like layer of tegument densities that enmesh and stabilize HCMV capsids. Based on this atomic detail, we designed several peptides targeting pp150nt. Our data show significant reduction in virus growth upon treatment with one of these peptides (pep-CR2) with an IC50 of 1.33 μM and no significant impact on cell viability. Based on 3D modeling, pep-CR2 specifically interferes with the pp150–capsid binding interface. Cells pre-treated with pep-CR2 and infected with HCMV sequester pp150 in the nucleus, indicating a mechanistic disruption of pp150 loading onto capsids and subsequent nuclear egress. Furthermore, pep-CR2 effectively inhibits mouse cytomegalovirus (MCMV) infection in cell culture, paving the way for future animal testing. Combined, these results indicate that CR2 of pp150 is amenable to targeting by a peptide inhibitor, and can be developed into an effective antiviral.
Frontiers Pandemics Throughout History
PDF) A novel Coltivirus-related virus isolated from free-tailed bats from Côte d'Ivoire is able to infect human cells in vitro
Viruses take center stage in cellular evolution, Genome Biology
Coloring Book of Germs and Viruses: Big coloring book full of cute virus alphabet and bacteria for toddler and kids ages 2-5: Publishing, Blue Finn: 9798706210540: : Books
How Do I Know If My Phone Has a Virus + Removing Them - Panda Security
Free Hand Drawn Viruses and Bacterias — Medialoot
Ms Sposion Man Nsp Download Size - Colaboratory
The science of the host–virus network
The ABCs of Malware A Small-Business Owner's Guide to Understanding, Preventing, and Budgeting for Online Attacks
Indian Journal of Dental Sciences - Free full text articles from Indian Journal of Dental Sciences
16 Best Free Bootable Antivirus Tools (September 2023)
Avast free antivirus. It may appear rational that anti-virus…, by Adamjorden
The Top 10 Worst Computer Viruses in History
Influenza and Other Respiratory Viruses - Wiley Online Library
How to Remove Virus from Laptop or PC Without Antivirus - EaseUS
Recomendado para você
-
News for June, 2023 - SCP Foundation21 outubro 2024
-
AETHELBEORN II IS FINALLY HERE!!!21 outubro 2024
-
This USB-C tester will tell you if your Apple chargers are genuine21 outubro 2024
-
Oral Surgery McAllen TX21 outubro 2024
-
The game is personalized for each player : r/LordsoftheFallen21 outubro 2024
-
Hestoth by GoredGuar on DeviantArt21 outubro 2024
-
Axnes AS on LinkedIn: #sar #hems #crew #lawenforcement #publicsafety21 outubro 2024
-
Mi Proyecto del curso: Modelado de personajes low poly para videojuegos21 outubro 2024
-
Total Confusion Game Convention (TotalCon)21 outubro 2024
-
Mooi wc : r/Hanwe21 outubro 2024
você pode gostar
-
Balrog (Devil Arm), Devil May Cry Wiki21 outubro 2024
-
Memes THG Jogos Vorazes Amino BR Amino21 outubro 2024
-
Laura Berlin - Laura Berlin added a new photo.21 outubro 2024
-
Como desenhar bolo arco íris kawaii ❤ desenhos para desenhar e pintar 😍 desenhando desenhos.21 outubro 2024
-
SHIPWRECKS AND SEA MONSTERS / California / Bay of Monterey21 outubro 2024
-
The Outer Worlds Review - Roller Coaster of Emotions and Travel21 outubro 2024
-
Qual o Pokemon Mais Forte no Pokemon UNITE21 outubro 2024
-
KaBuM! - www.kabum.com.br21 outubro 2024
-
Nintendo Wii U 32GB Console Splatoon Special Edition Bundle - Black21 outubro 2024
-
CLÍMAX: Dragon Ball Evolution é Eleito a Pior Adaptação Live21 outubro 2024