Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Fragile X mental retardation protein in intrahepatic

Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR

Pten heterozygosity restores neuronal morphology in fragile X

Pten heterozygosity restores neuronal morphology in fragile X

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

Mechanism-Based Treatments in Neurodevelopmental Disorders

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as

Dissociation of functional and structural plasticity of dendritic spines

Presynaptic FMRP and local protein synthesis support structural

IJMS, Free Full-Text