Molecules, Free Full-Text

Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.

Time Evolution Of Polarized Optical Microscopy Morphology Of Pla

Molecules, Free Full-Text

Molecules: The Elements And The Architecture Of Everything

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Mapping Single-Molecule Protein Complexes in 3D with DNA

Atoms and molecules : Weissbluth, Mitchel : Free Download, Borrow

Molecules An Open Access Journal from MDPI

Molecules An Open Access Journal from MDPI

Free Download Chemistry: A Molecular Approach 5th Ed. By Nivaldo J