IJMS, Free Full-Text
Por um escritor misterioso
Last updated 21 outubro 2024
Our recent study demonstrated that the CC-chemokine ligand 2 (CCL2) present in primary afferent fibers (PAFs) plays an important role in the microglia-dependent neuronal activation associated with zymosan-induced inflammatory pain. The present study was aimed to evaluate whether BD1047 (a prototypical sigma-1 receptor (Sig-1R) antagonist) is capable of modifying elevated levels of inflammation-evoked CCL2 as a peripheral antinociceptive mechanism. In DRG primary culture, zymosan dose-dependently increased CCL2 release from isolectin B4 (IB4)-positive DRG neurons, a process that was inhibited by co-culture with BD1047. Single treatment of BD1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as CCL2 expression in DRG neurons and microglia activation in the spinal dorsal horn. In the Complete Freund’s adjuvant (CFA)-induced inflammation model, repeated administration of BD1047 dramatically attenuated thermal hyperalgesia and mechanical hyperalgesia, and significantly diminished CCL2 immunoreactivity and microglia activation. Notably, CFA-induced inflammation significantly increased Sig-1R immunoreactivity in DRG neurons, which was co-localized with CCL2 and IB4, respectively. Taken together, our results suggest that BD1047′s anti-nociceptive property was substantially mediated by the inhibition of CCL2 release in unmyelinated PAFs and that this may, in turn, have attenuated the spinal microglia activation that is associated with inflammatory pain.
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS Free Full-Text Research Advances In Mechanical, 52% OFF
IJMS, Free Full-Text
IJMS, Free Full-Text
Pat Testing Labels Template Unique Ijms Free Full Text Genome Editing In Agriculture - Best Templates Ideas, Best Tem…
IJMS, Free Full-Text
IJMS, Free Full-Text, Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease, HTML
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
IJMS, Free Full-Text
IJMS, Free Full-Text
Recomendado para você
-
scariestmedia #brendanreviews #disturbingmovieiceberg #disturbingmovi21 outubro 2024
-
Disturbing Movies Iceberg - Page 221 outubro 2024
-
The Waiting Shed on X: Most Disturbed Person on Planet Earth I and II This tweet is a marker that I'm finally done with the second one (over 3 hours long). Mostly21 outubro 2024
-
Mdpope 1 to 3 explained|TikTok Search21 outubro 2024
-
MDPOPE โคตรหนังโหดของสายแข็งสุดขั้ว21 outubro 2024
-
EXHUMATION by MDPOPE on Music Unlimited21 outubro 2024
-
Chemokine Receptors in Allergy, Inflammation, and Infectious Disease21 outubro 2024
-
Increasing Salt Marsh Elevation Using Sediment Augmentation: Critical Insights from Surface Sediments and Sediment Cores21 outubro 2024
-
Micromachines, Free Full-Text21 outubro 2024
-
Has anyone on here seen Most Disturbed Person On Planet Earth 2 aka, MDPOPE 2? : r/horror21 outubro 2024
você pode gostar
-
Montevideo City Torque Brasil (@MvdCityTorqueBR) / X21 outubro 2024
-
22 Karats Saint Yevgeny Rodionovorthodox Icon GOLD LEAVES - Sweden21 outubro 2024
-
A história da Fábrica do Conhecimento de Paracambi - Diário do Rio de Janeiro21 outubro 2024
-
Pokemon Sleep Type Quiz. Find Your Style 100% Accurately21 outubro 2024
-
Osmdroid.net ▷ Observe Osm Droid News, OsmDroid.net21 outubro 2024
-
Naruto dublado em portugus portugal21 outubro 2024
-
RECAP: Demon Slayer: Kimetsu no Yaiba Swordsmith Village Arc21 outubro 2024
-
Sasaki To Miyano edit by hetalianxhoney on DeviantArt21 outubro 2024
-
CONVEYOR DELI - Play Online for Free!21 outubro 2024
-
The Last of Us Remastered PlayStation Hits PlayStation 4 3000287/3003513 - Best Buy21 outubro 2024