IJMS, Free Full-Text
Por um escritor misterioso
Last updated 13 abril 2025

The firm integration of anterior cruciate ligament (ACL) grafts into bones remains the most demanding challenge in ACL reconstruction, since graft loosening means graft failure. For a functional-tissue-engineered ACL substitute to be realized in future, robust bone attachment sites (entheses) have to be re-established. The latter comprise four tissue compartments (ligament, non-calcified and calcified fibrocartilage, separated by the tidemark, bone) forming a histological and biomechanical gradient at the attachment interface between the ACL and bone. The ACL enthesis is surrounded by the synovium and exposed to the intra-articular micromilieu. This review will picture and explain the peculiarities of these synovioentheseal complexes at the femoral and tibial attachment sites based on published data. Using this, emerging tissue engineering (TE) strategies addressing them will be discussed. Several material composites (e.g., polycaprolactone and silk fibroin) and manufacturing techniques (e.g., three-dimensional-/bio-printing, electrospinning, braiding and embroidering) have been applied to create zonal cell carriers (bi- or triphasic scaffolds) mimicking the ACL enthesis tissue gradients with appropriate topological parameters for zones. Functionalized or bioactive materials (e.g., collagen, tricalcium phosphate, hydroxyapatite and bioactive glass (BG)) or growth factors (e.g., bone morphogenetic proteins [BMP]-2) have been integrated to achieve the zone-dependent differentiation of precursor cells. However, the ACL entheses comprise individual (loading history) asymmetric and polar histoarchitectures. They result from the unique biomechanical microenvironment of overlapping tensile, compressive and shear forces involved in enthesis formation, maturation and maintenance. This review should provide a road map of key parameters to be considered in future in ACL interface TE approaches.

Ijms Free Full Text Delayed Onset Of Age Dependent Changes In Ultrastructure Of Myocardial 116100

IJMS Free Full-Text Immunoglobulin Abnormalities In Gaucher, 48% OFF

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF

Ijms Free Full Text Recent Advances In Pharmacological 74952
All articles in IJMS (ISSN 1422-0067) Vol 24, Issue 5, are now freely available to access, read and download: COVER STORY: Skin, By MDPI

IJMS, Free Full-Text

IJMS, Free Full-Text

IJMS Free Full-Text Research Advances In Mechanical, 52% OFF
Ijms Free Full Text The Effect Of The Chorion On Size
Ijms Free Full Text The Macrophages Microbiota Interplay In Irasutoya
Recomendado para você
-
Spider Silk, TibiaWiki13 abril 2025
-
Giant Spider, TibiaWiki13 abril 2025
-
VIRANDO EMPREENDEDOR $$$, TROCANDO SPIDER SILK POR SPOOL OF YARN13 abril 2025
-
Box plot comparing male black widow spider body size (mean13 abril 2025
-
Loading of the tibia–metatarsus joint of the hunting spider13 abril 2025
-
Play OTserver - Crie seu OTserver de Tibia - Várias Versões13 abril 2025
-
Abiels on Gladera – Forum – Tibia Bosses13 abril 2025
-
Spiders of the Carolinas13 abril 2025
-
The common spiders of the United States. Spiders. THE THERIDID13 abril 2025
-
Tibia MMORPG Sudden Death Rune SD T-Shirt tees blank t shirts13 abril 2025
você pode gostar
-
Inverted Colors13 abril 2025
-
Loot Chests: Chests and Mimics Addon for Minecraft13 abril 2025
-
Mighty Irish boys' names from myths and legends that people use to name kids today - Irish Star13 abril 2025
-
JORDAN MOGEY - JORDAN MOGEY - COWBOYS DRIFTERS & ANGELS CD IRISH COUNTRY MUSIC - Music13 abril 2025
-
WRRY – Sacrifice Lyrics13 abril 2025
-
One piece: Speculating on the role of Luffy's Gear 5 in the13 abril 2025
-
God Of War Ragnarök sequel teased by Tyr actor13 abril 2025
-
Knockout City Season 2 — Fight at the Movies Launch Trailer13 abril 2025
-
Hajime No Ippo Anime Paint By Numbers - Numeral Paint Kit13 abril 2025
-
Muito além do português e inglês: Conheça 6 idiomas que foram inventados13 abril 2025