Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

X chromosome regions. Regions in the X chromosome are: Xp (short arm)

X-Chromosome Inactivation and Skin Disease - ScienceDirect

Skewed X-inactivation is common in the general female population

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

X chromosome escape maps differ between mouse tissues. The position of

Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases - ScienceDirect

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing, Epigenetics & Chromatin

Frontiers Escape From X-Chromosome Inactivation: An Evolutionary Perspective

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

Chromatin environment and CTCF enrichment predispose gene silencing and